© - All Rights Reserved - Scott Atwood - University of California, Irvine
Applying multi-omics to basosquamous carcinoma
Gavin R. Long, Arinnae I. Kurdian, Scott X. Atwood
Journal of Investigative Dermatology. Accepted.
Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth
Tuyen T. L. Nguyen**, Kirsten N. Wong**, Ung Seop Jeon, Vama Jhumkhawala, Daniel Luy, Kevin C. Tan, Ishini Wickramatunga, Vinay Kumar, Whitney E. England, Linda T. Doan, Robert C. Spitale, Scott X. Atwood
bioRxiv
Leveraging gene correlations in single cell transcriptomic data
Kai Silkwood, Emmanuel Dollinger, Josh Gervin, Scott X. Atwood, Qing Nie, Arthur D. Lander
bioRxiv
Single cell transcriptomics of human skin equivalent organoids
Adam R. Stabell, Grace E. Lee, Yunlong Jia, Kirsten Wong, Shuxiong Wang, Ji Ling, Sandrine D. Nguyen, George L. Sen, Qing Nie, Scott X. Atwood
Cell Reports. 2023. 42(5):112511.
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bioRxiv
Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury
Natalia A. Veniaminova**, Yunlong Jia**, Adrien Hartigan, Thomas J. Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A. Dlugosz, Scott X. Atwood#, Sunny Y. Wong#
Cell Reports. 42(9):113121.
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bioRxiv
Screening cell-cell communication in spatial transcriptomics via collective optimal transport
Zixuan Cang, Yanxiang Zhao, Axel Almet, Adam Stabell, Raul Ramos, Maksim Plikus, Scott X. Atwood, Qing Nie
Nature Methods. 2023. 20(2):218-228.
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bioRxiv
Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment
Christian F. Guerrero-Juarez**, Gun Ho Lee**, Yingzi Liu, Shuxiong Wang, Matthew Karikomi, Yutong Sha, Rachel Y. Chow, Tuyen T.L. Nguyen, Venus Sosa Iglesias, Sumaira Aasi, Michael L. Drummond, Qing Nie, Kavita Sarin#, Scott X. Atwood#
Science Advances. 2022. 8(23):eabm7981.
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bioRxiv
Online engagement in an undergraduate cell biology course
Eric Tarapore**, Justin F. Shaffer**, Scott X. Atwood
Journal of College Science Teaching. 2022. 51(4):27-34.
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Exploiting enogenous enzymes for cancer-cell seletive metabolic labeling of RNA in vivo
Samantha Beasley, Abigail Vandewalle, Monika Singha, Kim Nguyen, Whitney England, Eric Tarapore, Nan Dai, Ivan Correa Jr., Scott X. Atwood, Robert C. Spitale
Journal of the American Chemical Society. 2022. 144(16):1085-7088.
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ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
A. Jane Bardwell, Beibei Wu, Kavita Y. Sarin, Marian L. Waterman, Scott X. Atwood, Lee Bardwell
Life Science Alliance. 2022. 5(11):e202101353.
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An optimized enzyme-nucleobase pair enables in vivo RNA metabolic labeling with improved cell-specificity
Monika K. Singha, Jan Zimak, Samantha R. Levine, Nan Dai, Chan Hong, Cecily Anaraki, Mrityunjay Gupta, Christopher J. Halbrook, Scott X. Atwood, Robert C. Spitale
Biochemistry. 2022. 61(23):2638-2642.
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MTOR promotes basal cell carcinoma growth through atypical PKC
Rachel Y. Chow, Taylor M. Levee, Gurleen Kaur, Daniel P. Cedeno, Linda T. Doan, Scott X. Atwood
Experimental Dermatology. 2021. 30(3):358-366.
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bioRxiv
PI3K promotes basal cell carcinoma through kinase-induced p21 degradation
Rachel Y. Chow, Ung Seop Jeon, Taylor M. Levee, Gurleen Kaur, Daniel P. Cedeno, Linda T. Doan, Scott X. Atwood
Frontiers in Oncology. 2021. 11:668247.
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Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models
Scott X. Atwood# and Maksim V. Plikus#
Experimental Dermatology. 2021. 30(3):298-303.
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Ovol1 regulates psoriasis-like skin inflammation and epidermal hyperplasia
Peng Sun, Remy Vu, Morgan Dragan, Daniel Haensel, Guadalupe Gutierrez, Quy Nguyen, Elyse Greenberg, Jie Wu, Scott X. Atwood, Eric Pearlman, Wei Han, Kai Kessenbrock, Xing Dai
Journal of Investigative Dermatology. 2021. 141(6):1542-1552.
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Single cell transcriptomics of human epidermis identifies basal stem cell transition states
Shuxiong Wang**, Michael L. Drummond**, Christian F. Guerrero-Juarez, Eric Tarapore, Adam L. MacLean, Adam R. Stabell, Stephanie C. Wu, Guadalupe Gutierrez, Bao T. That, Claudia A. Benavente,
Qing Nie#, Scott X. Atwood#
Nature Communications. 2020. 11(1): 4239.
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bioRxiv
Divergent resistance mechanisms to immunotherapy explain responses in different skin cancers
Emmanuel Dollinger**, Daniel R. Bergman, Peijie Zhou, Scott X. Atwood#, Qing Nie#
Cancers. 2020. 12(10): 2946.
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bioRxiv
AP-1 and TGFB cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen McKellar, Gautam Shankar, Sumaira Aasi, Kerri Rieger, Anthony E. Oro
Nature Communications. 2020. 11(1): 5079.
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Common skin diseases – skin cancer
Tuyen T.L. Nguyen**, Eric Tarapore**, Scott X. Atwood
Wiley. 2019. In Imaging technologies and transdermal delivery in skin disorders. https://doi.org/10.1002/9783527814633.ch5. ISBN: 978-3-527-34460-4.
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Defining the genetics of basosquamous carcinoma
Eric Tarapore and Scott X. Atwood
Journal of Investigative Dermatology. 2019. 139(11): 2258-60.
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Loss of primary cilia drives switching from Hedgehog to Ras pathway and basal cell to squamous cell carcinoma
Francois Kuonen**, Noelle E. Hiskey**, Gautam Shankar, Prajakta Jaju, Ramon J. Whitson, Kerri E. Rieger, Scott X. Atwood, Kavita Y. Sarin, Anthony E. Oro
Journal of Investigative Dermatology. 2019. 139(7):1439-48.
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Actin polymerization controls cilia-mediated signaling
Michael L. Drummond, Mischa Li, Eric Tarapore, Tuyen T.L. Nguyen, Baina J. Barouni, Shaun Cruz, Kevin C. Tan, Anthony E. Oro#, Scott X. Atwood#
Journal of Cell Biology. 2018. 217(9):3255-66.
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MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias
Alexander S. Brown, Pratap Meera, Banu Altindag, Ravi Chopra, Emma Perkins, Sharan Paul, Daniel R. Scoles, Eric Tarapore, Jessica Magri, Haoran Huang, Mandy Jackson, Vikram G. Shakkottai, Thomas S. Otis, Stefan M. Pulst,
Scott X. Atwood#, Anthony E. Oro#
Proceedings of the National Academy of Sciences. 2018. 115(52):E12407-E12416.
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bioRxiv
Illuminating alternative strategies to treat targeted chemotherapy-resistant sporadic basal cell carcinoma
Tuyen T.L. Nguyen and Scott X. Atwood
Journal of Investigative Dermatology. 2018. 138(5):1017-19.
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Noncanonical hedgehog pathway activation through SRF-MLK1 promotes drug resistance in basal cell carcinomas
Ramon J. Whitson, Alex Lee, Nicole M. Urman, Amar Mirza, Catherine Y. Yao, Alexander S. Brown, Jiang R. Li, Gautam Shankar, Micah A. Fry, Scott X. Atwood, Eunice Y. Lee, S. Tyler Hollmig, Sumaira Z. Aasi, Kavita Y. Sarin,
Matthew P. Scott, Ervin H. Epstein, Jean Y. Tang, Anthony E. Oro
Nature Medicine. 2018. 24(3):271-81.
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sm”FISH”ing for Hedgehog
Michael L. Drummond and Scott X. Atwood
Journal of Investigative Dermatology. 2017. 137(1):13-5.
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Cell-selective bioorthogonal metabolic labeling of RNA
Kim Nguyen**, Michael Fazio**, Miles Kubota, Sarah Nainar, Chao Feng, Xiang Li, Scott X. Atwood, Timothy W. Bredy, Robert C. Spitale
Journal of the American Chemical Society. 2017. 139(6):2148-51.
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Atypical Protein Kinase C - Histone Deacetylase 1 inhibitors cooperate in basal cell carcinoma treatment
Amar N. Mirza, Micah A. Fry, Nicole M. Urman, Scott X. Atwood, Jon Roffey, Gregory R. Ott, Bin Chen, Alex Lee, Alexander S. Brown, Sumaira Z. Aasi, Tyler Hollmig, Mark A. Ator, Bruce D. Dorsey, Bruce R. Ruggeri,
Craig A. Zificsak, Marina Sirota, Jean Y. Tang, Atul Butte, Ervin Epstein, Kavita Y. Sarin#, Anthony E. Oro#
JCI Insight. 2017. 2(21). pii: 97071.
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Tumor-derived Suppressor of Fused mutations reveal Hedgehog pathway interactions
Nicole M. Urman, Amar Mirza, Scott X. Atwood, Ramon J. Whitson, Kavita Y. Sarin, Jean Y. Tang, Anthony E. Oro
Plos One. 2016. 11(12):e0168031.
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Combined treatment with arsenic trioxide and itraconazole inhibits the Hedgehog pathway in patients with refractory metastatic basal cell carcinoma: results from a pilot trial
Mina S. Ally, Katherine Ransohoff, Kavita Sarin, Scott X. Atwood, Melika Rezaee, Irene Bailey-Healy, Jynho Kim, Philip A. Beachy, Anne Lynn S. Chang, Anthony Oro, Jean Y. Tang, A. Dimitrios Colevas
JAMA Dermatology. 2016. 152(4):452-6.
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Smoothened variants explain the majority of drug resistance in basal cell carcinoma
Scott X. Atwood**, Kavita Y. Sarin**, Ramon J. Whitson, Jiang R. Li, Geurim Kim, Melika Rezaee, Mina S. Ally, Jinah Kim, Catherine Yao, Anne L.S. Chang, Anthony E. Oro#, Jean Y. Tang#
Cancer Cell. 2015. 27(3):342-53.
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Rolling the genetic dice: neutral and deleterious Smoothened mutations in drug-resistant basal cell carcinoma
Scott X. Atwood, Kavita Y. Sarin, Jiang R. Li, Catherine Yao, Nicole M. Urman, Anne L.S. Chang, Jean Y. Tang, Anthony E. Oro
Journal of Investigative Dermatology. 2015. 135(8):2138-41.
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RAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors
Xuesong Zhao, Tatyana Ponomaryov, Kimberly J. Ornell, Pengcheng Zhou, Sukriti K. Dabral, Ekaterina Pak, Wei Li, Scott X. Atwood, Ramon J. Whitson, Anne Lynn S. Chang, Jiang Li, Anthony E. Oro, Jennifer A. Chan, Joseph F. Kelleher,
Rosalind A. Segal
Cancer Research. 2015. 75(17):3623-35.
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Mutations in the kinetochore gene KNSTRN in basal cell carcinoma
Prajakta Jaju, Christie B. Nguyen, Angela M. Mah, Scott X. Atwood, Jiang R. Li, Amin Zia, Anne L.S. Chang, Anthony E. Oro, Jean Y. Tang, Cari S. Lee, Kavita Y. Sarin
Journal of Investigative Dermatology. 2015. 135(12):3197-200.
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Advanced treatment for basal cell carcinomas
Scott X. Atwood, Ramon J. Whitson, Anthony E. Oro
Cold Spring Harbor Perspectives in Medicine. 2014. 4(7):a013581.
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"Atypical" regulation of Hedgehog-dependent cancer
Scott X. Atwood and Anthony E. Oro
Cancer Cell. 2014. 25(2):133-4.
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
Yujie Tang, Sharareh Gholamin, Simone Schubert, Minde I. Willardson, Alex Lee, Pratiti Bandopadhayay, Guillame Bergthold, Sabran Masoud, Brian Nguyen, Nujsaubnusi Vue, Brianna Balansay, Furong Yu, Sekyung Oh, Pamelyn Woo, Spenser Chen,
Anitha Ponnuswami, Michelle Monje, Scott X. Atwood, Ramon J. Whitson, Siddhartha Mitra, Samuel H. Cheshier, Jun Qi, Rameen Beroukhim, Jean Y. Tang, Rob Wechsler-Reya, Anthony E. Oro, Brian A. Link, James E. Bradner, Yoon-Jae Cho
Nature Medicine. 2014. 20(7):732-40.
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Identification of genes promoting skin youthfulness by genome-wide association study
Anne L.S. Chang, Gil Atzmon, Aviv Bergman, Samantha Brugmann, Scott X. Atwood, Howard Y. Chang, Nir Barzilai
Journal of Investigative Dermatology. 2014. 134(3):651-7.
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GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
Scott X. Atwood#, Mischa Li, Alex Lee, Jean Y. Tang, Anthony E. Oro#
Nature. 2013. 494(7438):484-8.
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Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration
Wei-Meng Woo**, Scott X. Atwood**, Hansen H. Zhen, Anthony E. Oro
Journal of Visualized Experiments. 2013. (72):e4344.
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"Patch"ing up our tumor signaling knowledge
Scott X. Atwood**, Ramon J. Whitson**, Anthony E. Oro
Journal of Investigative Dermatology. 2013. 133(5):1131-3.
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Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal cell carcinomas in Gorlin syndrome
Anne L.S. Chang, Scott X. Atwood, Danielle M. Tartar, Anthony E. Oro
JAMA Dermatology. 2013. 149(5):639-41.
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Hedgehog pathway inhibition and the race against tumor evolution
Scott X. Atwood, Anne L.S. Chang, Anthony E. Oro
Journal of Cell Biology. 2012. 199(2):193-7.
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Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement
Chiharu Graybill, Brett Wee, Scott X. Atwood, Kenneth E. Prehoda
Journal of Biological Chemistry. 2012. 287(25):21003-11.
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MIM and Cortactin antagonism regulates ciliogenesis and Hedgehog signaling
Marina Bershteyn, Scott X. Atwood, Wei-Meng Woo, Mischa Li, Anthony E. Oro
Developmental Cell. 2010. 19(2):270-83.
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aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division
Scott X. Atwood and Kenneth E. Prehoda
Current Biology. 2009. 19(9):723-9.
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Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC
Scott X. Atwood, Chiswili Chabu, Rhiannon R. Penkert, Chris Q. Doe, Kenneth E. Prehoda
Journal of Cell Science. 2007. 120(Pt 18):3200-6.
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© - All Rights Reserved - Scott Atwood - University of California, Irvine